Four young women born with missing or abnormal vaginas were implanted with lab-grown versions made from their own cells, the latest success in creating replacement organs that have so far included tracheas, bladders and urethras.
Follow-up tests show the new vaginas are indistinguishable from the women’s own tissue and have grown in size as the young women, who got the implants as teens, matured.
All four of the women are now sexually active and report normal vaginal function. Two of the four, who were born with a working uterus but no vagina, now menstruate normally.
It is not yet clear whether these women can bear children, but because they are menstruating, it suggests their ovaries are working, so it may be possible, said Dr Anthony Atala, director of Wake Forest Baptist Medical Centre’s Institute for Regenerative Medicine in North Carolina.
The feat, which Atala and colleagues in Mexico describe in the journal The Lancet, is the latest demonstration from the growing field of regenerative medicine, a discipline in which doctors take advantage of the body’s power to regrow and replace cells.
In prior studies, Atala’s team has used the approach to make replacement bladders and urine tubes or urethras in young boys.
Atala said the pilot study is the first to show that vaginal organs custom-built in the lab using patients’ own cells can be successfully used in humans, offering a new option for women who need reconstructive surgeries.
All four of the women in the study were born with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome, a rare genetic condition in which the vagina and uterus are underdeveloped or absent. You can read more about the condition here but please be warned that the article contains an image that may be too graphic for young readers.
Conventional treatment generally involves the use of grafts made from intestinal tissue or from skin, but both tissues have drawbacks, says Atala, a pediatric urologic surgeon at Wake Forest.
Intestinal tissue produces an excess of mucous, which can cause problems with odour. Conventional skin, meanwhile, can collapse.
Atala said women with this condition usually seek treatment as teenagers. “They can’t menstruate, especially when they have a severe defect where they don’t have an opening,” he said. This can cause abdominal pain as menstrual blood collects in the abdomen. “It has nowhere else to go,” he added.
Girls in the study were aged 13 and 18 at the time of the surgeries, which were performed between June 2005 and October 2008.