Helminthic therapy – ingesting live roundworms – is growing in popularity as a means of fighting various autoimmune disorders, but more evidence is needed of its efficacy, and the treatment is not approved in many countries.

Would you eat worms or their larvae to help cure what ails you?

Helminthic therapy – the deliberate ingestion of a controlled number of live parasitic roundworms called helminths – is gaining popularity in treating chronic autoimmune disorders such as multiple sclerosis, Crohn’s disease, inflammatory bowel disease and asthma.

Whipworm (Trichuris trichiura) is an example of a helminth that is typically used in this therapy.

How does it work?

According to Dr Sunny Wong, clinical assistant professor at the Institute of Digestive Disease at the Chinese University of Hong Kong, it is based on the hypothesis that many of these illnesses have a hyperactive immune component, which may be suppressed by the immune-regulating effects of the helminths once they have been ingested.

Helminthic therapy advocates believe that replenishing the intestinal biome by swallowing parasitic worms, and thereby “balancing out” an overactive immune system, can prevent it from causing harm.

A 2015 review published in the Journal Of Evolutionary Medicine estimated that up to 7,000 people worldwide are successfully self-treating inflammatory bowel disease, allergies and more with helminths.

Beneficial? Remains to be seen

This therapy is experimental, though, and whether this type of immunosuppression would be beneficial for certain diseases remains to be seen.

“In epidemiological studies, some populations with a higher prevalence of intestinal parasitic infections were shown to have lower incidences of inflammatory conditions, including rheumatoid arthritis and asthma,” says Dr Adrian Wu Young-yuen, a specialist in allergy and immunology at the Centre for Allergy and Asthma Care in Central.

“(But) the causal relationship is not established, since there could well be other determining factors.”

Is it safe?

There is also the question of helminthic therapy’s safety. “Nothing can be supposed in medicine – or science in general – until one has data from properly conducted experimental studies,” says Wu.

“Any symbiotic organisms living in the gastrointestinal tract exert an influence on the immune system. An alteration in this colony could potentially bring about changes that could be detrimental – or beneficial.”

Wong adds that, due to the lack of evidence regarding their safety, therapies with helminths should be conducted only in approved clinical trial settings.

Maintaining healthy gut microbiota can be done in simpler ways.

Maintaining gut health

There is no denying the importance of gut health to one’s overall physical and even mental health.

“Through the modulation of the immune system, the gut microbiota – the collective term for the trillions of microbes in the human gut – help our digestion, affect our energy levels and metabolism, and regulate our immunity,” says Wong.

“Importantly, the gut microbiota is found to be altered in diseases such as colorectal cancer, inflammatory bowel disease, diabetes, metabolic syndrome, cardiovascular diseases, and even neurological and psychiatric conditions. It is evident that the normal balance of these microbes is disrupted in many of these diseases.”

One of the safest and most effective ways to maintain gut health is to practise healthy lifestyle habits – having a balanced diet, sufficient sleep and exercise, and by avoiding unnecessary antibiotics that may disrupt the gut microbiota.

Treatment not approved for use

Helminthic therapy has been in use for centuries but most countries have not approved its use.

Thailand is one Asian country to allow the treatment, and Germany is awaiting approval to make worm eggs commercially available – but as a food ingredient, not as medicine.

If you want to try helminthic therapy you would be hard-pressed to find a medical professional who will administer it.

In addition, Wu says that if a treatment is experimental, an ethics committee needs to have approved its research protocol.

“As a doctor I can only offer treatments that have been approved by the regulatory authorities.” – South China Morning Post/Sasha Gonzales